Aubergine is a component of a nanos mRNA localization complex
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| Authors: | Becalska, AN; Kim, YR; Belletier, NG; Lerit, DA; Sinsimer, KS; Gavis, ER |
| Year: | 2011 |
| Journal: | Dev. Biol. 349: 46-52 Article Link (DOI) PubMed |
| Title: | Aubergine is a component of a nanos mRNA localization complex |
| Abstract: | Localization of nanos (nos) mRNA to the posterior pole of the Drosophila oocyte is essential for abdominal segmentation and germline development during embryogenesis. Posterior localization is mediated by a complex cis-acting localization signal in the nos 3' untranslated region that comprises multiple partially redundant elements. Genetic analysis suggests that this signal is recognized by RNA-binding proteins and associated factors that package nos mRNA into a localization competent ribonucleoprotein complex. However, functional redundancy among localization elements has made the identification of individual localization factors difficult. Indeed, only a single direct-acting nos localization factor, Rumpelstiltskin (Rump), has been identified thus far. Through a sensitized genetic screen, we have now identified the Argonaute family member Aubergine (Aub) as a nos localization factor. Aub interacts with nos mRNA in vivo and co-purifies with Rump in an RNA-dependent manner. Our results support a role for Aub, independent of its function in RNA silencing, as a component of a nos mRNA localization complex. (C) 2010 Elsevier Inc. All rights reserved. |
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