A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging
Back to previous page
| Authors: | Ludewig, AH; Kober-Eisermann, C; Weitzel, C; Bethke, A; Neubert, K; Gerisch, B; Hutter, H; Antebi, A |
| Year: | 2004 |
| Journal: | Genes & Development 18: 2120-2133 |
| Title: | A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging |
| Abstract: | Environmental cues transduced by an endocrine network converge on Caenorhabditis elegans nuclear receptor DAF-12 to mediate arrest at dauer diapause or continuous larval development. In adults, DAF-12 selects long-lived or short-lived modes. How these organismal choices are molecularly specified is unknown. Here we show that coregulator DIN-1 and DAF-12 physically and genetically interact to instruct organismal fates. Homologous to human corepressor SHARP, DIN-1 comes in long (L) and short (S) isoforms, which are nuclear localized but have distinct functions. DIN-1L, has embryonic and larval developmental roles. DIN-1S, along with DAF-12, regulates lipid metabolism, larval stage-specific programs, diapause, and longevity. Epistasis experiments reveal that din-1S acts in the dauer pathways downstream of lipophilic hormone, insulin/IGF, and TGFP signaling, the same point as daf-12. We propose that the DIN-1S/DAF-12 complex serves as a molecular switch that implements slow life history alternatives in response to diminished hormonal signals. |
Please send suggestions for improving this publication database to
sass-support@sfu.ca.
Departmental members may update their publication list.