UNC-39, the C-elegans homolog of the human myotonic dystrophy-associated homeodomain protein Six5, regulates cell motility and differentiation
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| Authors: | Yanowitz, JL; Shakir, MA; Hedgecock, E; Hutter, H; Fire, AZ; Lundquist, EA |
| Year: | 2004 |
| Journal: | Developmental Biology 272: 389-402 |
| Title: | UNC-39, the C-elegans homolog of the human myotonic dystrophy-associated homeodomain protein Six5, regulates cell motility and differentiation |
| Abstract: | Mutations in the unc-39 gene of C elegans lead to migration and differentiation defects in a subset of mesodermal and ectodermal cells, including muscles and neurons. Defects include mesodermal specification and differentiation as well a neuronal migration and axon pathfinding defects. Molecular analysis revealed that unc-39 corresponds to the previously named gene ceh-35 and that the UNC-39 protein belongs to the Six4/5 family of homeodomain transcription factors and is similar to human Six5, a protein implicated in the pathogenesis of type I myotonic dystrophy (DM1). We show that human Six5 and UNC-39 are functional homologs, suggesting that further characterization of the C. elegans unc-39 gene might provide insight into the etiology of DM1. (C) 2004 Elsevier Inc. All rights reserved. |
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