A murine intraperitoneal infection model reveals that host resistance to Campylobacter jejuni is Nramp1 dependent.
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| Authors: | Champion OL, Valdez Y, Thorson L, Guttman JA, Menendez A, Gaynor EC, Finlay BB. |
| Year: | 2008 |
| Journal: | Microbes and Infection 10(8):922-7. Epub 2008 May 14. Article Link (DOI) |
| Title: | A murine intraperitoneal infection model reveals that host resistance to Campylobacter jejuni is Nramp1 dependent. |
| Abstract: | We tested the hypothesis that host resistance to Campylobacter jejuni is Nramp I dependent. Following intraperitoneal (IP) inoculation of Nramp1+/+ and isogenic Nramp1-deficient (Nramp1-/-) mice C. jejuni primarily associated with mac1-positive cells in liver tissue. A significant reduction of C. jejuni was observed in Nramp1 +/+ mice 4 days post-infection (PI) (liver) and 8 days PI cecum-colon. In contrast, Nramp1 -/- mice showed no significant reduction of C. jejuni and instead had a chronic inflammatory response and significant histopathological lesions 30 days PI. Differential cytokine profiles were observed in C. jejuni infected Nramp1 +/+ and Nramp1 -/- primary dendritic cells. Taken together these data indicate that Nramp I is critical for host resistance to C. jejuni. (c) 2008 Elsevier Masson SAS. All rights reserved. |
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