mex-1 and the general partitioning of cell fate in the early C-elegans embryo
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| Authors: | Schnabel, R; Weigner, C; Hutter, H; Feichtinger, R; Schnabel, H |
| Year: | 1996 |
| Journal: | Mechanisms of Development 54: 133-147 Article Link (DOI) |
| Title: | mex-1 and the general partitioning of cell fate in the early C-elegans embryo |
| Abstract: | It is thought that at least some of the initial specification of the five somatic founder cells of the C. elegans embryo occurs cell-autonomously through the segregation of factors during cell divisions. It has been suggested that in embryos from mothers homozygous for mutations in the maternal-effect gene mex-1, four blastomeres of the 8-cell embryo adopt the fate of the MS blastomere. It was proposed that mex-1 functions to localise or regulate factors that determine the fate of this blastomere. Here, a detailed cell lineage analysis of 9 mex-1 mutants reveals that the fates of all somatic founder cells are affected by mutations in this gene. We propose that mex-1, like the par genes, is involved in establishing the initial polarity of the embryo. |
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