GLP-1 AND INDUCTIONS ESTABLISHING EMBRYONIC AXES IN C-ELEGANS
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| Authors: | HUTTER, H; SCHNABEL, R |
| Year: | 1994 |
| Journal: | Development 120: 2051-2064 |
| Title: | GLP-1 AND INDUCTIONS ESTABLISHING EMBRYONIC AXES IN C-ELEGANS |
| Abstract: | Two successive inductions specify blastomere identities, that is complex cell lineages and not specific tissues, in a major part of the early C. elegans embryo. The first induction acts along the anterior-posterior axis of the embryo and the second along the left-right axis. During the first induction a specific lineage program is induced in the posterior of the two AB blastomeres present in the four cell embryo. During the second induction, almost ail of the left-right differences of the embryo are specified by interactions between a single signalling blastomere, MS, and the AB blastomeres that surround it. In both cases the inductions break the equivalence of pairs of blastomeres. The inductions correlate with the cell-cell contacts to the inducing blastomeres. The stereotype cleavage pattern of the early embryo results in invariant cell-cell contacts that guarantee the specificity of the inductions. Both inductions are affected in embryos mutant for glp-1 suggesting that in both cases glp-1 is involved in the reception of the signal. |
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