The Effects of the Organic Flame-Retardant 1,2-Dibromo-4-(1,2-dibromoethyl) Cyclohexane (TBECH) on Androgen Signaling in Human Prostate Cancer Cell Lines
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| Authors: | Wong, LIL; Reers, AR; Currier, HA; Williams, TD; Cox, ME; Elliott, JE; Beischlag, TV |
| Year: | 2016 |
| Journal: | Journal of Biochemical and Molecular Toxicology 30: 239-242 Article Link (DOI) |
| Title: | The Effects of the Organic Flame-Retardant 1,2-Dibromo-4-(1,2-dibromoethyl) Cyclohexane (TBECH) on Androgen Signaling in Human Prostate Cancer Cell Lines |
| Abstract: | The effects of the organic flame retardant 1,2-Dibromo-4-(1,2-dibromoethyl) cyclohexane (TBECH) on androgen receptor target gene expression were examined in the human LNCaP prostate cancer cell line. While gamma-/delta-TBECH alone led to a significant increase in prostate-specific antigen (PSA) mRNA accumulation, both the alpha-/-TBECH and gamma-/delta-TBECH mixtures repressed androgen-inducible PSA mRNA and protein accumulation in human LNCaP cells. Thus, we hypothesize that isomeric mixtures of TBECH may act as partial agonists of the androgen receptor. (C) 2015 Wiley Periodicals, Inc. |
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