Chemoprevention of Lung Squamous Cell Carcinoma in Mice by a Mixture of Chinese Herbs
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| Authors: | Wang, Y; Zhang, ZQ; Garbow, JR; Rowland, DJ; Lubet, RA; Sit, D; Law, F; You, M |
| Year: | 2009 |
| Journal: | Cancer Prevention Research 2: 634-640 Article Link (DOI) |
| Title: | Chemoprevention of Lung Squamous Cell Carcinoma in Mice by a Mixture of Chinese Herbs |
| Abstract: | Antitumor B (ATB) is a Chinese herbal mixture of six plants. Previous studies have shown significant chemopreventive efficacy of ATB against human esophageal and lung cancers. We have recently developed a new mouse model for lung squamous cell carcinomas (SCC). In this study, lung SCC mouse model was characterized using small-animal imaging techniques (magnetic resonance imaging and computed tomography). ATB decreased lung SCC significantly (3.1-fold; P<0.05) and increased lung hyperplastic lesions by 2.4-fold (P<0.05). This observation suggests that ATB can block hyperplasia from progression to SCC. ATB tissue distribution was determined using matrine as a marker chemical. We found that ATB is rapidly absorbed and then distributes to various tissues including the lung. These results indicate that ATB is a potent chemopreventive agent against the development of mouse lung SCCs. |
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